Pet rabbit mated with wild rabbit - any special advice about offspring?

We have a pet rabbit about 16 months old that we rescued from an owner who could no longer care for her. We think she is a giant rabbit - has butterfly type markings but we have very little info.

She escaped recently and mated with a local wild rabbit, so we now have 5 kits, all apparently healthy and thriving. Are there any special concerns dealing with such offspring? Will they be more susceptible to disease for example?

Any help please

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